N-Methyl-2-pyrrolidone

Takaitaccen Bayani:

Sunan samfur:N-Methyl-2-pyrrolidone

Ma’ana:M-PYROL (R) ppm (ta KF)); N-Methyl-2-pyrrolidone Manufacturer;1-METHYL-2-PYRROLIDONE, REAGENT (ACS) 1-METHYL-2-PYRROLIDONE, REAGENT (ACS) 1-METHYL-2-PYRROLIDONE, REAGENT ACS); 1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone; N-Methyl-2-pyrrolidinone 872-50-4 NMP; 1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9N

MW:99.13

EINECS:212-828-1

Rukunin samfur:NMP; Kayan aikin sinadarai; UV/Vis); GC Headspace Solvents; GC Solvents; Solutions don aikace-aikacen GC; ACS da Reagent Rarraba Magani; ACS Grade; ACS Grade Solvents; Gwangwani Karfe tare da Zaren NPT; Karfe mai nauyi; Narke don LC- ICP-MS;Toxins (banda magungunan kashe qwari/sauran ƙwayoyi); Aikace-aikace; Binciken Abin sha; Tubalan Ginin; C4 zuwa C8; Sinthesis na Chemical; Abinci &; GC-MS Solvents; Tubalan Ginin Heterocyclic; ICP-OES/-MS;Pyrrolidines; Reagents for Inorganic Trace Analysis Aikace-aikace; Madadin Makamashi; Amber Glass Bottles; Analytical Reagents; Analytical/Chromatography; CHROMASOLV Plus; Chromatography Reagents &; Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV); Maganin Halitta; Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru (CHROMASOLV); NMR ;Tabbas/Hatimi?kwalabe;872-50-4;bc0001

Fayil Mol:872-50-4.mol

Aika mana imel

Cikakken Bayani

Tags samfurin

Pyrrolidone Chemical Properties

Wurin narkewa	-24 ° C (launi)
Wurin tafasa	202 °C (lit.) 81-82 °C/10 mmHg (lit.)
yawa	1.028 g/ml a 25 °C (lit.)
yawan tururi	3.4 (Vs iska)
tururi matsa lamba	0.29 mm Hg (20 ° C)
refractive index	n20/D 1.479
Fp	187 °F
yanayin ajiya.	Adana a zazzabi +5°C zuwa +30°C.
narkewa	ethanol: miscible0.1ML/ml, bayyananne, mara launi (10%, v/v)
tsari	Ruwa
pka	-0.41± 0.20 (An annabta)
launi	≤20 (APHA)
PH	8.5-10.0 (100g/l, H2O, 20 ℃)
wari	Dan kamshin amin
Farashin PH	7.7-8.0
m iyaka	1.3-9.5% (V)
Ruwan Solubility	= 10 g/100 ml a 20ºC
M	Hygroscopic
max	283nm (MeOH) (lit.)
Merck	14,6117
BRN	Farashin 106420
Kwanciyar hankali:	Barga, amma yakan rube bayan fallasa haske.Mai ƙonewa.Ba tare da jituwa tare da magungunan oxidizing masu karfi, acid mai karfi, rage yawan wakilai, tushe.
InChiKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 a 25 ℃
Bayanan Bayani na CAS DataBase	872-50-4(CAS DataBase Reference)
Bayanin Chemistry NIST	2-Pyrrolidinone, 1-methyl-(872-50-4)
Tsarin Rijistar Abun EPA	N-Methyl-2-pyrrolidone (872-50-4)

Bayanin Tsaro

Lambobin haɗari	T, Xi
Bayanin Hatsari	45-65-36/38-36/37/38-61-10-46
Bayanan Tsaro	41-45-53-62-26
WGK Jamus	1
RTECS	Farashin 5790000
F	3-8-10
Zazzabi Na atomatik	518 °F
Farashin TSCA	Y
HS Code	2933199090
Bayanan Abubuwa masu haɗari	872-50-4(Bayanan Abubuwa masu haɗari)
Guba	LD50 baki a cikin zomo: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg

Amfanin Pyrrolidone da Ƙarfafawa

Abubuwan Sinadarai	N-Methyl-2-pyrrolidone ruwa ne mara launi zuwa haske rawaya mai haske tare da ɗan ƙamshin ammonia.N-Methyl-2-pyrrolidone gaba ɗaya ba shi da ruwa.Yana da narkewa sosai a cikin ƙananan barasa, ƙananan ketones, ether, ethyl acetate, chloroform, da benzene da matsakaici mai narkewa a cikin hydrocarbons aliphatic.N-Methyl-2-pyrrolidone yana da ƙarfi hygroscopic, ingantaccen sinadari, ba mai lalacewa ba ga ƙarfe na carbon da aluminum, kuma ɗan lalacewa zuwa jan ƙarfe.Yana da ƙarancin mannewa, sinadarai mai ƙarfi da kwanciyar hankali na thermal, babban polarity, da ƙarancin ƙarfi.Wannan samfurin yana da ɗanɗano mai guba, kuma ƙayyadaddun da aka yarda da shi a cikin iska shine 100ppm. N-Methyl-2-pyrrolidone wani kaushi ne da ake amfani da shi a cikin masana'antu da aikace-aikace iri-iri, kamar fenti da cirewa, sarrafa man petrochemical, kayan aikin filastik injiniya, sinadarai na aikin gona, tsabtace lantarki da tsabtace masana'antu / gida.
Amfani	N-Methyl-2-pyrrolidone (NMP) wani ƙarfi ne na polar aprotic wanda ke da fa'idodin ƙarancin guba, babban wurin tafasa, ƙwaƙƙwaran ƙarfi, zaɓi mai ƙarfi da kwanciyar hankali.Ana amfani dashi ko'ina don tsarkakewa na hakar hydrocarbon, acetylene, olefins, da diolefins. Ana amfani da shi a cikin tsaftacewa na masana'antu, kuma yana aiki a matsayin mai narkewa don samar da magungunan kashe qwari, robobi na injiniya, sutura, filaye na roba, da kuma haɗaɗɗen da'irori. Hakanan za'a iya amfani dashi azaman mai tsabtace masana'antu, mai watsawa, rini, mai mai da daskarewa. N-Methyl-2-pyrrolidone ne mai kyau ƙarfi ƙarfi, yadu amfani a aromatics hakar, lubricating mai tacewa, acetylene wadatar, butadiene rabuwa da kira gas desulfurization. Ana amfani da iskar gas desulfurization, lubricating mai tacewa, lubricating man antifreeze, olefin hakar, kuma a matsayin sauran ƙarfi ga insoluble injiniya robobi polymerization. Ana iya amfani da shi a cikin maganin ciyawa, don tsaftace kayan rufi, kayan aikin masana'antu na semiconductor da allunan da'ira, don sake sarrafa sharar PVC, azaman abin wanka, ƙarin rini da wakili mai tarwatsawa. Ana amfani dashi a cikin matsakaici don halayen polymerization kamar robobin injiniya da fiber aramid. Ana amfani da N-Methyl-2-pyrrolidone azaman kaushin fluoride na polyvinylidene da kayan taimako na lantarki don batirin lithium ion. babban darajar tsabta don gano ICP-MS. Don haɓakar peptide.
guba	Na baka (mus) LD50:5130 mg/kg; Baka (bera) LD50:3914 mg/kg; Dermal (rbt) LD50:8000 mg/kg.
Sharar gida	Tuntuɓi dokokin jiha, na gida ko na ƙasa don zubar da kyau.Dole ne a zubar da shi bisa ga ƙa'idodin hukuma.Ruwa, idan ya cancanta tare da wakilai masu tsabta.
ajiya	N-Methyl-2-pyrrolidone shine hygroscopic (yana ɗaukar danshi) amma barga a ƙarƙashin yanayin al'ada.Zai yi ƙarfi da ƙarfi tare da oxidizers masu ƙarfi irin su hydrogen peroxide, nitric acid, sulfuric acid, da sauransu. Abubuwan bazuwar farko suna haifar da hayakin carbon monoxide da nitrogen oxide tururi.Yakamata a guji yawan fallasa ko zubewa a matsayin al'amari mai kyau.Kamfanin Kemikal na Lyondell yana ba da shawarar sanya safofin hannu na butyl lokacin amfani da N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone yakamata a adana shi a cikin tsaftataccen ƙarfe mai laushi mai phenolic ko ganguna.Teflon®1 da Kalrez®1 an nuna su zama kayan gasket masu dacewa.Da fatan za a yi bitar MSDS kafin a sarrafa.
Bayani	N-Methyl-2-pyrrolidone ne mai aprotic sauran ƙarfi tare da fadi da kewayon aikace-aikace: petrochemical aiki, surface shafi, dyes da pigments, masana'antu da kuma gida tsaftacewa mahadi, da noma da Pharmaceutical formulations.Yana da ban haushi, amma kuma ya haifar da lokuta da yawa na lamba dermatitis a cikin ƙaramin kamfani na lantarki.
Abubuwan Sinadarai	N-Methyl-2-pyrrolidone ruwa ne mara launi ko rawaya mai haske tare da warin amine.Yana iya fuskantar yawan halayen sinadarai ko da yake an yarda da shi azaman tsayayyen ƙarfi.Yana da juriya ga hydrolysis a ƙarƙashin yanayin tsaka tsaki, amma acid mai ƙarfi ko tushen jiyya yana haifar da buɗe zobe zuwa 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone za a iya rage zuwa 1-methyl pyrrolidine tare da borohydride.Jiyya tare da magungunan chlorinating yana haifar da samuwar amide, tsaka-tsakin da za a iya samun ƙarin canji, yayin da jiyya tare da amyl nitrate yana haifar da nitrate.Ana iya ƙara Olefins zuwa matsayi na 3 ta hanyar jiyya da farko tare da oxalic esters, sannan tare da aldehyes masu dacewa (Hort da Anderson 1982).
Amfani	N-Methyl-2-pyrrolidone wani kaushi ne na iyakacin duniya wanda ake amfani dashi a cikin sinadarai na kwayoyin halitta da kuma polymer chemistry.Manyan sikelin aikace-aikace sun haɗa da farfadowa da tsarkakewa na acetylenes, olefins, da diolefins, gas tsarkakewa, da kuma hakar aromatics daga feedstocks.N-Methyl-2-pyrrolidone ne m masana'antu sauran ƙarfi.A halin yanzu an amince da NMP don amfani kawai a cikin magungunan dabbobi.Ƙayyadaddun yanayi da metabolism na NMP a cikin bera zai ba da gudummawa ga fahimtar toxicology na wannan sinadari na waje wanda mutum zai iya fallasa shi da yawa.
Amfani	Mai narkewa don resins masu zafin jiki;sarrafa petrochemical, a cikin masana'antun masana'anta na microelectronics, dyes da pigments, masana'antu da mahaɗan tsabtace gida;tsarin noma da magunguna
Amfani	N-Methyl-2-pyrrolidone, yana da amfani ga spectrophotometry, chromatography da gano ICP-MS.
Ma'anarsa	ChEBI: Memba na nau'in pyrrolidine-2-wanda shine pyrrolidin-2-daya wanda aka maye gurbin hydrogen da aka haɗe zuwa nitrogen da ƙungiyar methyl.
Hanyoyin samarwa	N-Methyl-2-pyrrolidone an ƙera shi ta hanyar ra'ayi na buytrolactone tare da methylamine (Hawley 1977).Sauran matakai sun haɗa da shiri ta hanyar hydrogenation na mafita na maleic ko succinic acid tare da methylamine (Hort da Anderson 1982).Masu kera wannan sinadari sun haɗa da Lachat Chemical, Inc, Mequon, Wisconsin da GAF Corporation, Covert City, California.
Magana (s) na Ƙarfafawa	Haruffa Tetrahedron, 24, shafi.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
Babban Bayani	N-Methyl-2-Pyrrolidone (NMP) wani ƙarfi ne, aprotic sauran ƙarfi tare da babban ƙarfi, da ƙarancin ƙarfi.Wannan mara launi, babban tafasa, babban madaidaicin walƙiya da ƙarancin tururi yana ɗauke da ƙamshi mai kama da amine.NMP yana da babban sinadari da kwanciyar hankali na zafi kuma gaba ɗaya ba shi da ruwa da ruwa a duk yanayin zafi.NMP na iya aiki azaman mai narkewa tare da ruwa, alcohols, glycol ethers, ketones, da abubuwan kamshi/chlorinated hydrocarbons.NMP duka biyun ana iya sake yin amfani da su ta hanyar distillation kuma a shirye suke.Ba a samun NMP akan jerin gurɓataccen iska mai haɗari (HAPs) na 1990 na Dokar Tsabtace Tsabtace.
Ra'ayin Iska & Ruwa	Mai narkewa cikin ruwa.
Bayanin Reactivity	Wannan aminin tushe ne na sinadarai mai laushi.N-Methyl-2-pyrrolidone yakan kawar da acid don samar da gishiri da ruwa.Adadin zafin da ya samo asali a kowane mole na amine a cikin tsaka tsaki ya bambanta da ƙarfin amine a matsayin tushe.Amines na iya zama rashin jituwa da isocyanates, halogenated organics, peroxides, phenols (acid), epoxides, anhydrides, da acid halides.Gaseous hydrogen mai flammable ana samar da amines a hade tare da masu rage ƙarfi masu ƙarfi, kamar hydrides.
Hazard	Tsananin fata da kumburin ido.Ƙarƙashin fashewa - 2.2-12.2%.
Hatsarin Lafiya	Shakar zafi mai zafi na iya harzuka hanci da makogwaro.Ciwo yana haifar da haushin baki da ciki.Saduwa da idanu yana haifar da haushi.Maimaituwa da tsayin hulɗar fata yana haifar da laushi, haushi na wucin gadi.
Wuta Hazard	Hatsari na Musamman na Samfuran Konewa: Ana iya ƙirƙirar oxides masu guba na nitrogen a cikin wuta.
Flammability da Explosibility	Mara ƙonewa
Amfanin masana'antu	1) N-Methyl-2-pyrrolidone ana amfani dashi azaman mai ƙarfi mai ƙarfi na dipolar aprotic, barga da rashin aiki; 2) don hakar hydrocarbons na ƙanshi daga mai mai mai; 3) don kawar da carbon dioxide a cikin masu samar da ammonia; 4) azaman sauran ƙarfi don halayen polymerization da polymers; 5) a matsayin mai cire fenti; 6) don magungunan kashe qwari (USEPA 1985). Sauran abubuwan da ba na masana'antu ba na N-Methyl-2-pyrrolidone sun dogara ne akan kaddarorin sa a matsayin rarrabuwar kaushi mai dacewa da nazarin sinadarai na lantarki da na jiki (Langan and Salman 1987).Aikace-aikacen harhada magunguna suna amfani da kaddarorin N-Methyl-2-pyrrolidone azaman haɓakar shigar ciki don ƙarin saurin canja wurin abubuwa ta cikin fata (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).An amince da N-Methyl-2-pyrrolidone azaman kaushi don aikace-aikacen slimicide zuwa kayan tattara kayan abinci (USDA 1986).
Tuntuɓi allergens	N-Methyl-2-pyrrolidone ne mai aprotic sauran ƙarfi tare da fadi da kewayon aikace-aikace: petrochemical aiki, surface shafi, dyes da pigments, masana'antu da kuma gida tsaftacewa mahadi, da noma da Pharmaceutical formulations.Yana da ban sha'awa, amma yana iya haifar da dermatitis mai tsanani saboda tsawon lokaci.
Bayanan Tsaro	Guba ta hanyar jijiya.Matsakaicin mai guba ta hanyar ciki da hanyoyin intraperitoneal.Ƙananan mai guba ta hanyar haɗuwa da fata.Teratogen na gwaji.Tasirin haifuwa na gwaji.An ruwaito bayanan maye gurbi.Mai ƙonewa lokacin da aka fallasa ga zafi, buɗewar harshen wuta, ko oxidizers masu ƙarfi.Don yaƙar wuta, yi amfani da kumfa, CO2, busassun sinadarai.Lokacin da zafi ya lalace yana fitar da hayaki mai guba na NOx.
Cutar sankarau	An fallasa berayen zuwa N-Methyl-2-pyrrolidone tururi a 0, 0.04, ko 0.4 mg / L don 6 h / rana, 5 kwana / mako don shekaru 2. Ratsi na maza a 0.4 mg / L sun nuna dan kadan rage ma'anar nauyin jiki.Ba a lura da tasirin mai guba ko ciwon daji na rayuwa ba a cikin berayen da aka fallasa don shekaru 2 zuwa ko dai 0.04 ko 0.4mg/L na N-Methyl-2-pyrrolidone.Ta hanyar dermal, rukuni na 32 mice sun karbi kashi na farawa na 25mg na N-Methyl-2-pyrrolidone bayan makonni 2 ta hanyar aikace-aikacen ƙwayar ƙwayar ƙwayar ƙwayar cuta phorbol myristate acetate, sau uku a mako, fiye da 25 makonni.Dimethylcarbamoyl chloride da dimethylbenzanthracene sun yi aiki azaman ingantattun sarrafawa.Kodayake ƙungiyar N-Methyl-2-pyrrolidone tana da ciwace-ciwacen fata guda uku, ba a yi la'akari da wannan amsa mai mahimmanci ba idan aka kwatanta da na abubuwan sarrafawa masu kyau.
Hanyar metabolic	Ana gudanar da berayen rediyo mai lakabin N-methyl-2-pyrrolidinone (NMP), kuma babbar hanyar fitar berayen ita ce ta fitsari.Babban metabolite, wakiltar 70-75% na kashi da aka gudanar, shine 4- (methylamino) butenoic acid.Wannan samfurin da ba shi da tushe zai iya samuwa daga kawar da ruwa, kuma ƙungiyar hydroxyl na iya kasancewa akan metabolite kafin acid hydrolysis.
Metabolism	Maza Sprague-Dawley berayen an ba su allurar intraperitoneal guda ɗaya (45 mg/kg) na radiyo mai lamba 1 -methyl-2-pyrrolidone.An kula da matakan plasma na rediyoactivity da fili na tsawon sa'o'i shida kuma sakamakon ya ba da shawarar saurin rarrabawa wanda ya biyo bayan lokacin kawar da jinkirin.An fitar da babban adadin lakabin a cikin fitsari a cikin sa'o'i 12 kuma ya kai kusan kashi 75% na adadin da aka yiwa alama.Sa'o'i ashirin da hudu bayan kashi, tarawar hazo (fitsari) ya kai kusan 80% na kashi.An yi amfani da nau'in zobe- da nau'in methyl-labeled, da kuma duka biyu [¹⁴C] - da [3H] -lakabi l-methyl-2-pyrrolidone.An kiyaye ma'auni na farko masu lakabi a cikin sa'o'i 6 na farko bayan kashi.Bayan sa'o'i 6, an gano hanta da hanji sun ƙunshi mafi girman tarin radiyo, kusan 2-4% na kashi.An sami ƙaramin aikin rediyo a cikin bile ko iska mai shaƙatawa.Babban aikin ruwa chromatography na fitsari ya nuna kasancewar manyan guda ɗaya da ƙananan metabolites guda biyu.Babban metabolite (70-75% na kashi na rediyoaktif da ake gudanarwa) an bincika ta hanyar ruwa chromatography-mass spectrometry da gas chromatography-mass spectrometry kuma an ba da shawarar zama 3- ko 5-hydroxy-l-methyl-2-pyrrolidone (Wells). 1987).
Hanyoyin Tsarkakewa	Bushe pyrrolidone ta hanyar cire ruwa azaman * benzene azeotrope.Rarraba juzu'i a 10 torr ta hanyar ginshiƙi-cm 100 cike da helices gilashi.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride yana da m 86-88o (daga EtOH ko Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]