| Abubuwan Sinadarai | Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) mara launi ne zuwa fari zuwa lu'ulu'u masu rawaya, ƙaƙƙarfan taro ko ruwa mai tsabta.Yana narkewa a kusa da zafin jiki (mp=23°C).Ba ya rubewa a wannan ko ma daɗaɗɗen yanayin zafi.Misali, yawanci ana tsarkake ta ta hanyar distillation a ƙarƙashin rage matsa lamba a yanayin zafi har zuwa kusan 65 ° C.A yanayin zafi mafi girma zai rushe zuwa isobutene, t-butyl barasa da carbon dioxide. |
| Amfani | Di-tert-butyl dicarbonate (Boc2O) shine reagent da aka yi amfani da shi sosai don gabatar da ƙungiyoyin kariya a cikin haɗin peptide.Yana taka muhimmiyar rawa a cikin shirye-shiryen 6-acetyl-1,2,3,4-tetrahydropyridine ta hanyar amsawa tare da 2-piperidone.Yana aiki azaman ƙungiyar karewa da aka yi amfani da ita a cikin ƙayyadaddun lokaci peptide kira. |
| Shiri | A shirye-shiryen Di-tert-butyl dicarbonate ne kamar haka: A monoester sodium gishiri bayani da aka kara 2g na N, N-dimethylformamide, 1g na pyridine, 1g na triethylamine, Cooling zuwa -5 ~ 0 ° C, 60g diphosgene aka sannu a hankali. ƙara juzu'i a cikin 1.5h juzu'in juzu'i ya cika, dumama zuwa zazzabi na ɗaki (25 ° C), an sanya shi don 2h, an ba da izinin amsawa ya tsaya bayan tacewa, wankewar kwayoyin halitta.Dried tare da anhydrous magnesium sulfate, da sauran ƙarfi da aka distilled kashe a yanayi matsa lamba don ba da danyen samfurin 65 ~ 70g.Bayan sanyaya da crystallization, 57-60g na di-tert-butyl dicarbonate aka samu a cikin wani yawan amfanin ƙasa na 60-63%. |
| Ma'anarsa | ChEBI: Di-tert-butyl dicarbonate shine acyclic carboxylic anhydride.Yana da alaƙa da aiki da dicarbonic acid. |
| Martani | Halin da aka maye gurbin anilines tare da Boc2O a gaban adadin stoichiometric na 4-dimethylaminopyridine (DMAP) a cikin inert sauran ƙarfi (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) a dakin da zafin jiki yana kaiwa ga aryl isocyyanates a cikin kusan yawan amfanin ƙasa. min.
Di-tert-butyl dicarbonate da 4- (dimethylamino) pyridine sun sake duba.Halin su tare da amines da barasa |
| Babban Bayani | Di-tert- butyl dicarbonate (Boc2O) shine reagent wanda akafi amfani dashi don gabatarwar ƙungiyar kare Boc zuwa ayyukan amintattu.Hakanan ana amfani dashi azaman wakili mai bushewa a cikin wasu halayen kwayoyin halitta, musamman tare da acid carboxylic, wasu rukunin hydroxyl, ko tare da nitroalkanes na farko. |
| Hazard | Wani abu mai ban haushi wanda zai iya haifar da mummunan rauni na ido;Zai iya haifar da hankalin fata;Mai guba mai guba ta hanyar shaka |
| Flammability da Explosibility | Mai ƙonewa |
| Hanyoyin Tsarkakewa | Narke ester ta dumama a ~ 35o, kuma sanya shi a cikin injin daskarewa.Idan IR da NMR (1810m 1765 cm-1, a cikin CCl4 1.50 singlet) suna ba da shawarar mafi ƙarancin ƙazanta, sannan a wanke tare da daidaitaccen ƙarar H2O mai ɗauke da citric acid don yin Layer na ruwa mai ɗanɗano acidic, tattara ma'adinan Organic kuma bushe shi akan MgSO4 mai anhydrous. da kuma sanya shi a cikin wani wuri.[Papap et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] WUTA. |
